Ultrasound-Assisted Extraction of Antimalarial Compounds from the Bidara Laut (Strychnos ligustrina) Heartwood

Authors

  • Sri Familasari Department of Forest Products, Faculty of Forestry and Environment, IPB University
  • Rita Kartika Sari Department of Forest Products, Faculty of Forestry and Environment, IPB University
  • Wasrin Syafii Department of Forest Products, Faculty of Forestry and Environment, IPB University
  • Anne Carolina Department of Forest Products, Faculty of Forestry and Environment, IPB University
  • Umi Cahyaningsih Department of Animal Diseases and Veterinary Public Health, School of Veterinary Medicine and Biomedical Sciences, IPB University
  • Siti Sa'diah Department of Anatomy, Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, IPB University

DOI:

https://doi.org/10.23960/jsl.v11i3.682

Abstract

The aqueous wood extract of bidara laut (Strychnos ligustrina) from maceration demonstrated the greatest antimalarial activity against Plasmodium falciparum strain 3D7. However, this method has several limitations, including a lengthy extraction time, which allows for microorganism contamination. The aim of this study was to quantify the yield, evaluate the antimalarial effectiveness of the P. falciparum growth in-vitro, and analyze the aqueous bidara laut heartwood extracts phytochemical composition from the two different extraction methods,  namely the method of maceration extraction for 24 hours and the ultrasound-assisted extraction (UAE) for 30 (UAE30), 45 (UAE45), and 60 (UAE60) minutes. The bidara laut heartwood extract from the UAE60 method had relatively similar yield and antimalarial activity with the bidara laut heartwood extract from the UAE45 method. However, these extracts had higher yield and antimalarial activity than the extracts from the maceration and the UAE30 methods. The results of LC-MS/MS analysis revealed that the main compounds in the UAE45 and UAE60 extracts were strychnine, quinaprilat, and 3,4-bis-cyclobut-3-ene-1,2-dione, which has potent antimalarial properties.

Keywords: antimalarial activity, Plasmodium falciparum, quinaprilat, strychnine, Strychnos ligustrina

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Published

03-08-2023

How to Cite

Familasari, S., Sari, R. K., Syafii, W., Carolina, A., Cahyaningsih, U., & Sa’diah, S. . (2023). Ultrasound-Assisted Extraction of Antimalarial Compounds from the Bidara Laut (Strychnos ligustrina) Heartwood. Jurnal Sylva Lestari, 11(3), 360–369. https://doi.org/10.23960/jsl.v11i3.682

Issue

Vol. 11 No. 3 (2023): September

Section

Articles

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Copyright (c) 2023 Sri Familasari, Rita Kartika Sari, Wasrin Syafii, Anne Carolina, Umi Cahyaningsih, Siti Sa'diah

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